Hojjat Sadeghi-aliabadi , PhD
School :School of Pharmacy and Pharmaceutical Sciences
Department :Department of Medicinal Chemistry
Research Center :Isfahan Pharmaceutical Research center
work address :Pharm Chem Dept. School of Pharmacy, Isfahan univ. of Medical Sciences, Hezar Jarib St., Isfahan, Iran
1989 Doctor of Pharmacy - IUMSHS, 1996 Ph.D in pharmaceutical chemistry, School of Pharmacy, University of Bradford, Bradford West Yorkshire, BD7 1DP, United Kingdom. Post doc. In toxicology and cell biology, School of Pharmacy, University of Toronto, Canada.
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Hojjat Sadeghi-aliabadi received his Pharm D. degree from , Isfahan University of Medical Sciences, Isfahan, Iran, in 1988 with the highest honors, and Ph.D. degrees in Medicinal chemistry in 1996 from University of Bradford, UK.From 1996 till now he is an academic member of School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran. In 2003-4 he spent one year sabbatical with Prof. O’Brian at the school of Pharmacy, Toronto, ON, Canada, as a Postdoctoral Research Scholar. He is now a Professor in Medicinal Chemistry Department , Isfahan University of Medical Sciences, Isfahan, Iran.
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Research Experience :
Sadeghi-aliabadi H., Mohammadi V. and Jafarian A. “Synthesis and analysis of some novel derivatives of anthraquinones for the treatment of breast cancer” Pharmaceutical sciences, Journal of faculty of pharmacy, Tabriz university of medical sciences, Autumn and winter 2003, No. 2, pp 63-74. Sadeghi-aliabadi H., Emami A., Saeidi M. and Jafarian A. “Cytotoxic effects of the extract of Iranian Taxus bacata and Cupresus horizentalic on cancer cells” Iranian Journal of Pharmaceuticl Research (2003) 107-110. Fassihi A., Sadeghi-aliabadi H., Zarghi A. and Shafiee A. “Synthesis and evaluation of calcium channel antagonist activity of new 1,4-dihydropyridines containing phenylamineimidazolyl substitute guinea-pig ileal smooth muscle” Journal of Research in Medical sciences (2004), 9, 5-10. Sadeghi-aliabadi H. and Ahmadi A. “Cytotoxicity and antitumor properties of a marine compound on cancer cells (HESA-A)” Medical Journal of Islamic Academy of Sciences (2003), 13, 55-61. Zarghi A., Sadeghi-aliabadi H., Fassihi A. and Shafiee A. “Synthesis and calcium antagonist activity of 1,4-dihydropyridines containing phenylaminoimidazolyl substituents.” IL Farmaco (2003), 58(11), 1077-1081. Sadeghi-aliabadi H., Tabarzadi M. and Zarghi A. “Synthesis and cytotoxic evaluation of two novel anthraquinone derivatives.” IL Farmaco (2004), 59(8), 645-649. Sadeghi-aliabadi H. and Brown J. “Synthesis, analysis and biological evaluation of novel steroidal oestrogenic prodrugs for the treatment of breast cancer.” Pharmaceutical Biology (2004), 42(4-5), 367-373. Emami A., Sadeghi-aliabadi H., Saeidi M. and Jafarian A. “Cytotoxic evaluation of Iranian conifers on cancer cells” Pharmaceutical Biology (2005), 43(4), 1-6. Ahmad Movahedian, Hojjat Sadeghi-aliabadi, Alireza Ghannadi, Mahin Gharavi, and Sepideh Azarpajooh." Hypolipidemic Activity of Allium purrum L. in Cholesterol-Fed Rabbits " Journal of Medicinal Food. 2006;9(1):98-101. Hojjat Sadeghi-Aliabadi, Nasrollah Ghasemi , Ali Fatahi." Cytotoxic Effects of Iranian Mistletoe Extract on a Panel of Cancer Cells " Iranian journal of Pharmaceutical sciences (IJPS). 2006;2(3):157-162. Hojjat Sadeghi-aliabadi, Katie Khan, Hans-Joachim Lehmler, Larry W. Robertson and Peter J. O’Brien." Molecular Cytotoxic Mechanisms of Catecholic Polychlorinated Biphenyl Metabolites in isolated rat hepatocytes" Chemico-Biological Interactions. 2007;167:184-192. Hojjat Sadeghi-aliabadi, Abbas Jafarian, Seyed Ali Fatemi, Gholamhossain Shahidi and Seyed Ahmad Emami." Evaluation of cytotoxicity of some Iranian conifers extracts, using Saccharomyces cerevisiae, RS 322N and RS 188N" Research In Pharmaceutical Sciences. 2007;1(2):66-72. Hojjat Sadeghi-aliabadi, Gholamreza Asghari, Sayed Abolfazl Mostafavi, Abolghasem Esmaeili. "Solvent optimization on Taxol extraction from Taxus baccata L., using HPLC and LC-MS" Daru, 2009; 17 (3): Naser Tavakoli, Mahdi Ghodrati, Nasrollah Ghasemi-dehkordi, Hojjat Sadeghi-aliabadi. Formation and evaluation of a new herbal tablet from strawberry and Grape leaves. Jundishapor Journal of Natural Pharmaceutical Products. 2008; 3(1): 19-25. Sagha M, Karbalaie K, Tanhaee S, Esfandiari E, Salehi H, Sadeghi-Aliabadi H, Razavi S, Nasr-Esfahani MH, Baharvand H. Neural induction in mouse embryonic stem cells by co-culturing with chicken somites. Stem Cells Dev. 2009 May 12. [Epub ahead of print]. Fassihi A, Azadpour Z, Delbari N, Saghaie L, Memarian HR, Sabet R, Alborzi A, Miri R, Pourabbas B, Mardaneh J, Mousavi P, Moeinifard B, Sadeghi-Aliabadi H. Synthesis and antitubercular activity of novel 4-substituted imidazolyl-2,6-dimethyl-N3,N5-bisaryl-1,4-dihydropyridine-3,5-dicarboxamides. Eur J Med Chem. 2009; 44(8):3253-8. Hojjat Sadeghi-aliabadi, Mohsen Minaiyan, Azadeh Dabestan. Cytotoxic evaluation of doxorubicin in combination with simvastatin against human cancer cells. Res Pharmaceu Sci (RPS); 2010; 5(2): 127-133. Ashkan Heidarkhan Tehrani, Ali zadhoush, Saeed Karbasi, Hojjat Sadeghi-aliabadi. Scaffold percolative efficiency: in vitro evaluation of the structural criterion for electrospun mats. J Mater Sci: Mater med; 2010; 21: 2989-2998. Abbas palizban, Hojjat Sadeghi-aliabadi, Foad Abdollahpour. Effect of cerium lanthanide on Hela and MCF-7 cancer cell growth in the presence of transferrin. Res Pharmaceu Sci (RPS); 2010; 5(2): 119-125. Lotfollah Saghaie, Hojjat Sadeghi-aliabadi, Mahdi Kafiri. Synthesis and biological evaluation of bidentate 3-hydroxypyridin-4-ones iron chelating agents. Res Pharmaceu Sci (RPS); 2011; 6(2): 117-122. Mina Mirrian, Afshin Zarghi, Sedighe Sadeghi, Parisa Tabaraki, Mojdeh Toolai, Orkideh Dadras, Hojjat Sadeghi-aliabadi. Synthesis and cytotoxic evaluation of some novel sulfonamide derivatives against a few human cancer cells. IJPR; 2011; 10(4): 741-748. Jalleh Varshosaz, Hojjat Sadeghi-aliabadi, Faezeh Shafieepoor. Biological safety evaluation of stealth solid lipid nanoparticles of risperidone…. Farmacia; 2012; 60 (1), 64-79. Behshid Behdadfar, Ahmad Kermanpoor, Hojjat Sadeghi-aliabadi, Mariya Morrales, Morteza Mozafari. Synthesis of High intrinsic loss power aqueous ferrofluids of iron oxide nanoparticles by citric acid-assisted hydrothermal-reduction route. J of Solid State Chemistry; 2012; 187: 20-26. Behshid Behdadfar, Ahmad Kermanpoor, Hojjat Sadeghi-aliabadi, Mariya Morrales, Morteza Mozafari. Synthesis of aqueous ferrofluids of ZnxFe3xO4 nanoparticles by citric acid-assisted hydrothermal-reduction route for magnetic hyperthermia applications. J of Magnetism and magnetic Material; 2012; 324: 2211-2217. Hojjat Sadeghi-aliabadi, Hossein Mossavi, Mina Mirriyan, Saeed Kakhaki, Afshin Zarghi, The cytotoxic and synergistic effects of Flavonoid derivatives on doxorubicin cytotoxicity in Hela, MDA-MB-231 and HT-29 cancer cells. Iranian Journal of Toxicology; 2012; 15(5): 558-564. Jalleh Varshosaz, Hojjat Sadeghi-aliabadi, Farshid Hasanzadeh, Sareh Andalib. Synthesis of octadecylamine-retinoic acid conjugate for enhanced cytotoxic effects of 5-FU using LDL targeted nanostructured lipid carriers. European J Medicinal Chemistry; 2012; 54: 429-438. Jalleh Varshosaz, Hojjat Sadeghi-aliabadi, Farshid Hasanzadeh, Majid Shakeri. ّFolate targeted solid lipid nanoparticles of simvastatin for enhanced cytotoxic effects of doxorubicin in chronic myeloid leukemia. Current Nanoscience; 2012; 8: 249-258. Mohamad Tavakoli, Ensiyeh Bateni, Mansoor Rismanchiyan, Mohamad Hossein Fathi, Ali DostMohamadi, Azim Rabiee, Hojjat Sadeghi-aliabadi, Mahmood Etebari, Mina Miriyan. Genotoxicity effects of nano bioactive glass and Novabone bioglass on gingival fibroblasts using single cell gel electrophoresis (comet assay): an in vitro study. Dental Research Journal; 2012; 9(3): 314-320. Jalleh Varshosaz, Farshid Hasanzadeh, Hojjat Sadeghi-aliabadi, Mostafa Khadem. Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma. J Liposome Res.; 2012; 22(3): 224-36. Jaleh Varshosaz, Farshid Hasanzadeh, Hojjat Sadeghi-aliabadi, Farzin Firozian, and Mina Mirian. Effect of MolecularWeight and Molar Ratio of Dextran on Self-Assembly of Dextran Stearate Polymeric Micelles as Nanocarriers for Etoposide. Journal of Nanomaterials; 2012: 10 pages M. Nayebsadrian, Jaleh Varshosaz, Farshid Hasanzadeh, Hojjat Sadeghi-aliabadi,M. Banitalebi, M. Rostami. Screening the most effective variables on physical properties of folate-targeted dextran/retinoic acid micelles by Taguchi design. Journal of Nanomaterials; 2012: 7 pages. Fateme Shafiee, Hojjat Sadeghi-aliabadi, Farshid hasanzadeh. Evaluation of cytotoxic effects of several novel tetralin derivatives against Hela, MDA-MB-468 and MCF-7 cancer cells. Adv Biomed Res; 2012; 1(4): 76-81. Kazem karami, Mahboube Hosseini, Hojjat Sadeghi-aliabadi, Janusz Lipkowski, Mina Mirian. Dinuclear bridged biphosphinic and mononuclear cyclopalladated complexes of benzylamines: Synthesis, structural characterization and antitumor activity. Polyhedron; 2012; 50: 187-192. Sare Andalib, Jaleh Varshosaz, Farshid Hassanzadeh, Hojjat Sadeghi-aliabadi. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design. Advanced Biomedical Research; 2012; 1(3): 45. Fassihi, A., Mahnam, K., Moeinifard, B., Bahmanziari, M., Hojjat Sadeghi-aliabadi, Zarghi, A., Sabet, R., Salimi M., Mansourian, M. Synthesis, calcium-channel blocking activity, and conformational analysis of some novel 1,4-dihydropyridines: Application of PM3 and DFT computational metho. Medicinal Chemistry Research; 2012; 21: 2749-2761. L. Saghaie, Hojjat Sadeghi-aliabadi, M. Ashaeshoar. Synthesis, analysis and cytotoxic evaluation of some hydroxypyridinone derivatives on HeLa and K562 cell lines. Res Pharmaceu Sci (RPS); 2013; 8(3): 185-195. Hojjat Sadeghi-aliabadi, Maryam Aliasgharluo, Ali Fatahi, Mina Mirian, Mostafa Ghanadian. In vitro cytotoxic evaluation of some synthesized COX-2 inhibitor derivatives against a panel of human cancer cell lines. Res Pharmaceu Sci (RPS); 2013; 8(4): 299-304. Vajihe Akbari, Daryoush Abedi, Abbas Pardakhty, Hojjat Sadeghi-aliabadi. Ciprofloxacin nano-niosomes for targeting intracellular infections:an in vitro evaluation. J Nanopart Res; 2013; 15:1556. Hojjat Sadeghi-aliabadi, Morteza Mozaffari, Behshid Behdadfar, Maryam Raesizadeh, Hamid Zarkesh-Esfahani. Preparation and cytotoxic evaluation of magnetite (Fe3O4) nanoparticles on breast cancer cells and its combinatory effects with doxorubicin used in hyperthermia. Avicenna J Med Biotech; 2013; 5(2): 96-103. JalehVarshosaz, Farshid Hassanzadeh, Hojjat Sadeghi-aliabadi, Zahra Ghelich Khan, and M. Rostami. Retinoic Acid Decorated Albumin-Chitosan Nanoparticles for Targeted Delivery of Doxorubicin Hydrochloride in Hepatocellular Carcinoma. Journal of Nanomaterials; 2013; 12 pages. Hojjat Sadeghi-aliabadi, Lotfollah Saghaie, Nariman Tadayonnia, Mina Mirian. Hydroxypyridinone derivatives: synthesis and cytotoxic evaluation. Journal of Reports in Pharmaceutical Sciences; 2013; 2(1): 5-15. Mansour Rismanchian; Niloufar Khodaeian; Lida Bahramian; Mohammad hosein Fathi; Hojjat Sadeghi-aliabadi. In-vitro Comparison of Cytotoxicity of Two Bioactive Glasses in Micropowder and Nanopowder forms. Iranian Journal Pharmaceutical Research; 2013; 12(3): 437-443. Amir abbas Momtazi-borojeni, Mandana Behbahani1, Hojjat Sadeghi-aliabadi. Antiproliferative Activity and Apoptosis Induction of Crude Extract and Fractions of Avicennia Marina. Iranian Journal of Basic Medical Sciences (IJBMS). 2013; 16: 1203-1208. J. Varshosaz, Hojjat Sadeghi-aliabadi, S. Ghasemi, and B. Behdadfar. Use of Magnetic Folate-Dextran-Retinoic Acid Micelles for Dual Targeting of Doxorubicin in Breast Cancer. Biomed Research International; 2013:1-16. Jaleh Varshosaz, Farshid Hasanzadeh, Hojjat Sadeghi-aliabadi, and Farzin Firozian. Uptake of etoposide in CT-26 cells of colorectal cancer using folate targeted dextran-stearate polymeric micelles. Biomed Research International; 2013:11. Karami K, Hosseini-Kharat M, Hojjat Sadeghi-aliabadi, Lipkowski J, Mirian M. In vitro cytotoxicity studies of palladacyclic complexes containing the symmetric diphosphine bridging ligand. Studies of their interactions with DNA and BSA. European Journal of Medicinal Chemistry; 2013; 73C: 8-17. J. Varshosaz, Farshid Hassanzadeh, Hojjat Sadeghi-aliabadi, Mohammad Nayebsadrian, Mehnush Banitalebi and Mahboobeh Rostami. Synthesis and characterization of folate-targeted dextran/retinoic acid micelles for doxorubicin delivery in acute leukemia. Biomed Research International. 2014; 14 pages. J. Varshosaz, Farshid Hassanzadeh, Hojjat Sadeghi-aliabadi, Z. Larian and Mahboobeh Rostami. Synthesis of Pluronic® F127-poly (methyl vinyl ether-alt-maleic acid) copolymer and production of its micelles for doxorubicin delivery in breast cancer. Chemical Engineering Journal; 2014; 240: 133-146. Fatemeh Hendijani, Hojjat Sadeghi-aliabadi, Shaghayegh Haghjooy Javanmard. Comparison of human mesenchymal stem cells isolated by explants culture method from entire umbilical cord and Wharton’s jelly matrix. Cell and Tissue Banking; 2014; 11 pages. Parviz Mohammadi Ghalaei, J. Varshosaz and Hojjat Sadeghi-aliabadi. Evaluating cytotoxicity of hyaluronate targeted solid lipid nanoparticles of etoposide on SK-OV-3 cells. Journal of Drug Delivery; 2014; 746325: 7 pages. Mohamad Kazemi, Mandana Deilamian, mina mirian, Hojjat Sadeghi-aliabadi, Laleh Maleknia, Pertti Nousiainen and Ali Harlin. Nanofibrous chitosan-polyethylene oxide engineered scaffolds: A comparative study between simulated structural characteristics and cells viability. Biomed Research International; 2014; 438065: 9 pages. Mahboubeh Rezazadeh, Jaber Emami, farshid hasanzadeh, Hojjat Sadeghi-aliabadi, Mohsen Minaiyan, Abolfazl Mostafavi, Mahboubeh Rostami, Afsaneh Lavasani. In vivo pharmacokinetics, biodistribution and anti-tumor effect of paclitaxel-loaded targeted chitosan-based polymeric micelle. Drug Delivery; 2014. Jaber Emami, Mahboubeh Rezazadeh, farshid hasanzadeh, Hojjat Sadeghi-aliabadi, Mohsen Minaiyan, Abolfazl Mostafavi, Mahboubeh Rostami, Afsaneh Lavasani. Co-delivery of paclitaxel and a-tocopherol succinate by novel chitosan-based polymeric micelles for improving micellar stability and efficacious combination therapy. Drug development and industrial Pharmacy; 2014. Hojjat Sadeghi-aliabadi, Fatemeh Mohammadi, Hossain Fazeli, Maryam Mirlohi. Effects of Lactobacillus plantarum A7 with Probiotic Potential on Colon Cancer and Normal Cells Proliferation in Comparison with a Commercial Strain. Iranian Journal of Basic Medical Sciences; 2014; 17: 815-819. F. Hendijani, Sh. Haghjooy Javanmard, L. Rafiee and Hojjat Sadeghi-aliabadi. Effect of human Wharton’s jelly mesenchymal stem cell secretome on proliferation, apoptosis and drug resistance of lung cancer cells. Res Pharm Sci (RPS); 2015; 10: 134-142. Fatemeh Hendijani, Hojjat Sadeghi-aliabadi, Shaghayegh Haghjooy Javanmard. Human Wharton's jelly mesenchymal stem cell secretome display antiproliferative effect on leukemia cell line and produce additive cytotoxic effect in combination with doxorubicin. Tissue and Cell; 2015; 47: 229-234. Ali Fatahi, Mohammadhosssein Asgarshamsi, Farshid Hasanzadeh, Jaleh Varshosaz, Mahbobeh Rostami, Mina Mirian, Hojjat Sadeghi-aliabadi. Methotrexate-grafted-oligochitosan micells as drug carriers: synthesis and biological evaluations. J Mater Sci: Mater Med; 2015: 26: 119-126. Hojjat Sadeghi-aliabadi, Jamal Hamzeh, Mina Mirian. Investigation of Astragalus honey and propolis extract's cytotoxic effect on two human cancer cell lines and their oncogen and proapoptotic gene expression profiles. Adv Biomed Res; 2015: 4: 42. Dormiani K, Mir Mohammad Sadeghi H, Sadeghi-Aliabadi H, Ghaedi K, Forouzanfar M, Baharvand H, Nasr-Esfahani MH. Long-term and efficient expression of human β-globin gene in a hematopoietic cell line using a new site-specific integrating non-viral system. Gene Therapy. 2015; 22: 663-674. Jaber Emami, Mahboubeh Rezazadeh, farshid hasanzadeh, Hojjat Sadeghi-aliabadi, Mohsen Minaiyan, Abolfazl Mostafavi, Mahboubeh Rostami, Neal Davies. Development and in vitro/ in vivo evaluation of a noveltargeted polymeric micelle for delivery of paclitaxel. International Journal of Biological Macromolecules. 2015; 80: 29-40. Maryam Abbasi, Hojjat Sadeghi-aliabadi, Farshid Hasanzadeh, Massoud Amanlou. Prediction of dual agents as an activator of mutant p53 and inhibitor of Hsp90 by docking, molecular dynamic simulation and virtual screening. Journal of Molecular Graphics and Modeling. 2015: 61: 186-195. Mohammad Kazemi, Amir Atashi, Hojjat Sadeghi-Aliabadi, Pertti Nousiainen, Ali Harlin. 3D Micro-Nano Structured Hybrid Scaffolds: An Investigation Into the Role of Nanofiber Coating on Viability, Proliferation and Differentiation of Seeded Mesenchymal Stem Cells. Journal of Nanoscience and Nanotechnology; 2016; 16(9); 9000-9007. Mostafa Safari, Younes Kamari, Mehran Ghiaci, Hojjat Sadeghi-aliabadi, Mina Mirian. Synthesis and characterization of Insulin/Zirconium phosphate@TiO2 hybrid composites for enhanced oral Insulin delivery applications. Drug Development and Industrial Pharmacy. 2016; 22: 1-9. J. Varshosaz, Farshid Hassanzadeh, H. Sadeghi-Aliabadi, B. Behdadfar. Targeted delivery of doxorubicin to breast cancer cells by magnetic LHRH chitosan bioconjugated nanoparticles. International Journal of Biological Macromolecules. 2016; 93: 1192-1205. Mina Mirian, Razieh Taghizadeh, Hossein Khanahmad, Mansour Salehi, Ali Jahanian-Najafabadi, Hojjat Sadeghi-aliabadi, Shirin Kouhpayeh. Exposition of hepatitis B surface antigen (HBsAg) on the surface of HEK293T cell and evaluation of its expression. Research in Pharmaceutical Sciences. 2016; 11(5): 366.
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