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Reza Nedaeinia

Reza Nedaeinia , MSc PhD

Assistant Professor



School :

School of Medicine

Department :

Department of Genetics and Molecular Biology

Research Center :

Pediatric Inherited Diseases Research Center

work address :

Pediatric Inherited Diseases Research Center
Research Institute for Primordial Prevention of Non-Communicable Disease
Isfahan University of Medical Sciences

Education :

1. 1996- 1999 B.Sc. in Biology (Major: Microbiology), (Awarded higher top grade student). 2000-2003 M.Sc. in Biology (Major: Microbiology), (Awarded higher top grade student). 2. The top researcher of JIHAD-E-KESHAVARZI in Fars province in 2005. 3. 2011-2016 PhD. in Medical biotechnology, Mashhad University of Medical Sciences (MUMS), Mashhad, Iran (Awarded higher top grade and the best scientific student). 4. The top researcher of Mashhad University of Medical Sciences (MUMS) in the research festival, 2017. 5. The top researcher of MUMS. in the research festival, 2016. 6. The top researcher of Vice Chancellery for food and drug, Isfahan University of Medical Sciences (MUI). 2011. 7. The top researcher of Vice Chancellery for food and drug, MUI. 2007.

Relevant Work Experience :

1. 2003-2005 Employee of Agricultural Research Center in Fars Province- Zarghan as a researcher. Participating in farms training /Giving assistance in the accomplishment of the research project of Take-all, preparing collection of plant pathogenic fungi, helping diagnosis of plant disease in agricultural farms in Fars region, giving assistance for doing research projects in process, screening antagonist factors of Take-all and soft rot bacteria in Fars region. 2. 2006- 2011 Employee of Microbiology Department, Vice Chancellery for food and drug in Isfahan as a supervisor/doing required tests on food ,cosmetics & sanitaries, doing study and research to increase information in regard to microbial tests of food ,cosmetics and sanitaries, doing technical and hygienic inspection from all production ,supply , storage and distribution centers of foodstuff, cosmetics and sanitaries and also doing the required legal and hygienic actions, presenting research projects in executive system, participating in the committees of national standards of Iran, being a member of research committee, being a member of suggestion council, having supervision on tests done by the experts of the department, participating in national projects such as PMS (Post marketing surveillance). 3. 2018-2019 Research Assistant professor of medical biotechnology, in Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences as a supervisor and researcher in Biomedical Sciences Department. 4. Since 2019 Research Assistant professor of medical biotechnology in Research Institute for Primordial Prevention of Non-Communicable Disease Isfahan University of Medical Sciences.

Professional Memberships & Qualification :

1. Iranian Biology Society 2. Iranian Society of Microbiology

Extra Curricular Activities/ Interest(personal url) :

My interests are: detection and identification of a disease with unknown etiology, the use of antisense oligonucleotides (ASO) to modulate gene expression with target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation, and programmed gene editing. Also, ASOs can be used as the therapeutic potential of cancer and cancer resistance to treatment. The use of ASO also targets microbial agents such as viruses. In addition, I have previously performed studies about Gapmer technology such as Locked nucleic acid (LNA) anti-miR-21 for inhibiting cell growth and invasive behaviors of a colorectal adenocarcinoma cell line. We have designed chicken embryo modeling to inhibition of cancer cell metastasis to the lung epithelium and their diagnosis by ALU-q PCR using the 2-ΔΔCT method.


Grants & Awards :

1. The top researcher of JIHAD-E-KESHAVARZI in Fars province in 2005. 2. The top researcher of Mashhad University of Medical Sciences (MUMS) in the research festival, 2017. 3. The top researcher of MUMS. in the research festival, 2016. 4. The top researcher of Vice Chancellery for food and drug, Isfahan University of Medical Sciences (MUI). 2011. 5. The top researcher of Vice Chancellery for food and drug, MUI. 2007.

Patents :

Presentations & Poster Sessions :

1- R.Nedaeinia¹ and A.Fassihiani².Reaction of sugar beet cultivars to Erwinia carotovora subsp. Betavasculorum the causal agent vascular necrosis and rot of sugar beet,16th Iranian Plant Protection Congress,23 Aug-1. Sept. 2004(Tabriz-Iran). 2- R.Nedaeinia ¹ and A.Fassihiani².Study on the strains of bacterial vascular necrosis and sugar beet soft rot in Fars province. 16th Iranian Plant Protection Congress,23 Aug-1 Sept.2004(Tabriz-Iran). 3- A.Fassihiani¹and R.Nedaeinia ².Host range of Erwinia carotovora subsp. betavasculorum the causal agent bacterial vascular necrosis and soft rot of sugar beet, 16th Iranian Plant Protection Congress,23 Aug-1 Sept. 2004(Tabriz-Iran). 4- R.Nedaeinia ¹ and A.Fassihiani². Etiology of Sugar Beet Soft Rot in Fars province, the 1st National Iranian Conference of Applied Microbiology, Alzahra University- July 2007(Tabriz-Iran). 5- S.Javadi_ R.Nedaeinia _M.Hejazi_M.Zahedi. Qualitative evaluation of hamburgers for supply in Isfahan in 2002, the 1st Congress of Food Safety and 52nd Congress of Medical News dated on 16 Oct.2007(Isfahan-Iran). 6- R.Nedaeinia¹ and A.Fassihiani²,Evaluation of physiological and biochemical diversity among Pectobacteriums,the causal agent for vascular necrosis of sugar beet in Fars province, the 1st Congress of Food Safety and 52nd Congress of Medical News dated on 16 Oct.2007(Isfahan-Iran). 8- S.Javadi_ R.Nedaeinia _M.Hejazi, Application of nanobiotechnology in food Industry, Islamic Azad University- jooybar branch. May 8, 2008(Jooybar-Iran).

Research Experience :

1. PhD thesis; Inhibition of microRNA-21 (miR-21) with locked nucleic acid technology (LNA) and evaluation of its inhibitory effects on proliferation of human colon adenocarcinoma cells. 2013- 2016. 2. Statistical study of the contamination of traditional and industrial ice creams with E. coli and optimization of E. coli identification methods in Isfahan. Iran. 2007- 2010. 3. Identification of subclinical mastitis-causing bacteria in industrial farms of Isfahan province by multiplex PCR method. 2009- 2011. 4. Preliminary study of the contamination of pasteurized milk with E. coli in Isfahan. 2010- 2011. 5. Supervisors, Investigation of protein profile of E. coli isolates obtained from traditional ice cream in Isfahan. Iran. 2011- 2014. M.Sc.- Food Industry. 6. Therapeutic effect of liposome containing antagomir 21 on melanoma cell metastasis in c57bl6 mice with effect on angiogenesis and stemness. 2014- 2020. 7. Production of matrigel from acellular rat intestinal tissue to be used in regenerative medicine and biological structure culture. 2022-. 8. Designing and Implementation of Software of “Quality Control Analysis of Milk and Dairy Products 2022-. 9. The role of non-coding RNA (ncRNA)s as a competitive endogenous RNA-network in diabetic condition; a systematic review and bioinformatic analysis,2022-. 10. Key transcription factors in pancreatic β cell differentiation and regulatory factors, and their role in the development of stem cell-derived insulin-producing cells: A review study, 2022-. 11. Investigation impact of LGR5 expression on clinicopathological characteristics and prognosis in cancer patients: A systematic review and meta-analysis, 2022-. 12. Impacts of type 2 diabetes drug family, dipeptidyl-peptidase 4 inhibitors, on common female malignancies: a systematic review, 2022-. 13. Investigation of prognosis and clinicopathological implications of APOBEC3B expression in breast and other cancers: A Systematic Review and Meta-Analysis, 2022-. 14. Evaluation status of integrin subunit alpha 4 promoter DNA hypermethylation in CRC and other malignant tumors: A Systematic Review and meta-analysis, 2022-. 15. Evaluation of targeted delivery of specific antisense oligonucleotides (ASOs) via engineered exosomes to combat COVID-19 disease and cytokine storm using human experimental 3D airway culture, 2022-. 16. Evaluation of the possibility of insulin-producing tissue by expressing Pax6-NeuroD1 gene constructs and inhibition of FOXO1 protein in rat intestinal organoid and evaluation of its therapeutic potential in rats with type 1 diabetes, 2022-. 17. Introduction and evaluation of new sodium-glucose co-transporter 2 inhibitors as type 2 anti-diabetes drug through in silico evaluations then evaluate the effects of in vivo on glycemic control, 2022-. 18. Inhibition of microRNA-21 with locked nucleic acid technology on expression of PDCD4 protein and its role in T-cell lymphocyte apoptosis in MS disease, 2021-. 19. Advisers; Optimization of lactic cheese production using salimix salt and oral lactic acid. 2015- 2017. M.Sc. Food Industry. 20. Advisers; Investigation of physicochemical and microbial properties of low fat yogurt enriched with wheat fiber. 2015- 2017. M.Sc.- Food Industry. 21. Advisers; Study of the effect of licorice essential oil in the form of frozen cover and modified atmospheric packaging on physicochemical and microbial properties of frozen shrimp. 2016-2018. M.Sc.- Food Industry. 22. Advisers; Study of the effect of Hollyhocks essential oil in the form of frozen cover and modified atmospheric packaging on physicochemical and microbial properties of shrimp. 2016- 2018. M.Sc.- Food Industry. 23. Supervisors, Inhibition of miR-21 in T lymphocytes and its effect on the expression of c-myc protein and its role of T cells apoptosis in MS disease. 2017- 2020. Ph.D.- Immunology. Mostafa Manian. 24. Inhibitory effects of MicroRNA-21 (miR-21) using Locked Nucleic Acid Technology (LNA) on PDCD4 protein expression and its role in T lymphocyte apoptosis in MS. Since 2019.

Research Interests :

My interests are: detection and identification of a disease with unknown etiology, the use of antisense oligonucleotides (ASO) to modulate gene expression with target degradation by RNase H-mediated cleavage, splicing modulation, non-coding RNA inhibition, gene activation, and programmed gene editing. Also, ASOs can be used as the therapeutic potential of cancer and cancer resistance to treatment. The use of ASO also targets microbial agents such as viruses. In addition, I have previously performed studies about Gapmer technology such as Locked nucleic acid (LNA) anti-miR-21 for inhibiting cell growth and invasive behaviors of a colorectal adenocarcinoma cell line. We have designed chicken embryo modeling to inhibition of cancer cell metastasis to the lung epithelium and their diagnosis by ALU-q PCR using the 2-ΔΔCT method.


Teaching Experience :

- Teaching in higher education centers:
1. Teaching 2 units of food biotechnology and 1 laboratory unit at the Islamic Azad University of Khorasgan, semester 96-97
2. Teaching 3 bio-cellular and molecular units and 1 unit of Shahid Rajaei Farhangian's laboratory in the 96-97 semester
3. Teaching genetic engineering and cloning in E.coli, Food and Drug Deputy, 2017
4. Transgenic agricultural products, Food and Drug Deputy, 2017
5. Teaching 4 units of cellular and molecular biology, 2 units of microbiology, 1 unit of microbe laboratory at Fatemeh Zahra University (S) Farhangian Semester 93-94
6. Teaching 4 units of cellular and molecular biology, 2 units of microbiology at Shahid Bahonar Farhangian Campus University, semester 93-94
7. Teaching 2 units of histology, 1 unit of histology laboratory at Shahid Bahonar Farhangian University, semester 1994-95
8. Teaching 2 units of human resource management in production and laboratory units of the academic year 1990-1991, the first semester of the bachelor's degree in food hygiene of animal origin at Amoresh Jihad Agriculture Center, Isfahan.
9. Teaching 2 units of principles of food quality control in the first semester of the academic year 1990-1991 to the Bachelor's degree in food hygiene of animal origin at Amoresh Jihad Agriculture Center in Isfahan.
10. Teaching 2 units of human resource management in production and laboratory units of the academic year 88-89, the second semester of the bachelor's degree in food hygiene with animal origin at the Amoresh Jihad Agricultural Center in Isfahan.
11. Teaching 2 units of principles of food quality control in the first semester of the academic year 1989-90 to the bachelor's degree in food hygiene of animal origin in Isfahan Jihad Agriculture Center
12. Teaching microbiology of food for 5 hours for undergraduate students of Environmental Health in 2016 at the Faculty of Health in the Vice-Chancellor of Food and Drug
13. 10 hours of specialized research topics in 1986 in the vice-chancellor of food and drugs
14. Internship course for food and cosmetic factories in the first semester of 2010-2014 for 20 hours for Bachelor of Nutrition students of the Faculty of Health in the Deputy Food and Drug Administration
15. Mentoring 2 units of research projects of the bachelor's course of the academic year 2010-2012 to the bachelor's degree in the health of materials of animal origin in Isfahan Jihad Agriculture Amoresh Center.
16. Internship course for food and cosmetic factories in the first semester of 2018-2018 for 9 hours for Bachelor of Nutrition students of the Faculty of Health in the Vice-Chancellor of Food and Medicine
-Teaching in the series of workshops of the Vice-Chancellor of Food and Drug and Environmental Health
1- The importance of GM in food products, Deputy Food and Drug Administration in 2017 and 2016
2- 30 hours of training for students of Isfahan University of Medical Sciences in the microbial department of the Deputy Food and Drug Administration in 2016
3- Training of standards and working methods of the Tehran General Administration in the microbiological department of the Deputy Food and Drug Administration of Kashan on 9/13/89
4- 119 hours of training program on the subject of microbial tests in the first six months of 2019 in the vice-chancellor of food and medicine with a bachelor's degree
5- 126 hours of training program on the subject of microbial experiments in the first six months of 2019 in the vice-chancellor of food and drugs who have a bachelor's degree
6- 52 hours of training program on the subject of microbial tests in the first six months of 2019 in the vice-chancellor of food and drugs who have a bachelor's degree
7- 7 hours of teaching on the topic of microbial testing of food in January 2019 for food and beverage experts and food control laboratory experts
8- 108 hours of teaching on the topic of microbial testing of food and health products in the first quarter of 2019 for technical officials with a bachelor's degree
9- 127 hours of teaching on the topic of microbial testing of food and health products in the second quarter of 2019 for technical officials with a bachelor's degree
10- 188 hours of teaching on the topic of microbial testing of food and health products in the third quarter of 2019 for technical officials with a bachelor's degree
11- 126 hours of microbial training in the third quarter of 2089 to the technical officials of the factories in the deputy food and drug department who have a bachelor's degree
12- Teaching the identification of types of fungi in food in 1988 to associates and environmental health experts of Health Center No. 2 for 12 hours with a bachelor's degree
13- 162 hours of microbiological training in the second half of 2088 to the technical officials of the factories in the Deputy Food and Drug Administration with a bachelor's degree
14- 180 hours of microbial training in the first six months of 2088 to the technical officials of the factories in the deputy food and drug department with a bachelor's degree
15- 210 hours of microbiological training in the first six months of 2087 to 52 technical officials of factories in the deputy food and drug department with a bachelor's degree
16- 81 hours of microbiological training in the second half of 2017 to 17 technical officials of factories in the deputy food and drug department with a bachelor's degree
17- Microbial control tests for pistachios, nuts, soybeans and dates from 2/2/86 and 6/21/86 for 8 hours, microbial control tests for tomatoes and ketchup dated 2/23/86 for 4 hours, microbial control tests Beans 9/2/86 and 21/6/86 for 8 hours, microbial control tests for paper napkins and towels 12/6/86 for 4 hours at the Deputy Food and Drug Administration with a bachelor's degree
18- Microbial control tests of confectionery products from 4/7/86 for 4 hours Microbial control tests of canned goods with pH less than 4.6 dated 7/10/86 for 4 hours Microbial control tests of dairy products 7/17/86 7/18/86 for 8 hours of microbial control tests for legumes, for 4 hours of 7/18/86 pasta microbial control tests, for 4 hours of 7/25/86 sausage microbial control tests, for 8 hours of water microbial control tests Packaged beverages 2/8/86 for 4 hours microbial control tests Paper towels 8/8/86 for 4 hours microbial control tests Non-carbonated fruit drink Nectar date 8/16/86 for 4 hours microbial control tests pickles and Shaurijat dated 8/16/86 for 4 hours, microbial control tests of soybeans, chickpea flour

Teaching Interests :

Cellular and molecular sciences, cancer biology, genetics and microbiology