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Hassan Dianat-Moghadam

Hassan Dianat-Moghadam , PhD

Assistant Professor



School :

School of Medicine

Department :

Department of Genetics and Molecular Biology

Research Center :

Pediatric Inherited Diseases Research Center

work address :

Isfahan University of Medical Sciences
Hezar Jerib street, Isfahan, Iran 8174673461

Education :

- Doctor of Philosophy (PhD) in Medical Biotechnology 2016-2021, Tabriz University of Medical Sciences - Master of Science (M.Sc.) Medical Biotechnology 2012-2015, Tehran University of Medical Sciences - Bachelor of Science (B.Sc.) Laboratory Sciences 2010-2014 , Shiraz University of Medical Sciences - AD. in Laboratory Sciences 2007 to 2009, Yazd Shahid Sadoughi University of Medical Sciences

Relevant Work Experience :

- Laboratory Technician, Microbiology portion, April 2013-September 2013, Tehran, Salamat Clinic, Shahr Rey-Javanmard Qassab - Laboratory Technician, Hematology portion, May 2014-Febrary 2014, Tehran, Specialized Obstetrics, Gynecology and Neonatology Shahid Akbarabadi Hospital

Professional Memberships & Qualification :

- Instructor of Laboratory, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran - Joint appointment in Pediatric Inherited Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran - Assistant professor, Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Extra Curricular Activities/ Interest(personal url) :

-Technology: Personal Web Site, Social Media, YouTube Channel - Sports and Recreation: Swimming, Gym - Music - Movie - Student Council - Poetry/Writing


Grants & Awards :

- Honorary Distinguished Scientific Student According to Section “K”-based assessment, Educational, Scientific and Welfare Institutions Special for Brilliant National Talents. - Design, construction, and characterization of a live attenuated Leishmania major (Centrin-/-, Tripanothion reductase-/- and Peteridine reductase-/-) and replacing knock out gene by LLO-BAX-R8, TK, and Polyepitop respectively; and evaluation of lesion size, parasite burden and cytokine pattern in Balb/c mice immunized by transgenic parasite and comparison with wild Leishmania major and evaluation of challenging response in immunized mice 2023 to present | Isfahan University of Medical Sciences (Isfahan, IR) Part of GRANT_NUMBER: IR.MUI.AEC.1402.002 - Evaluation and comparison of Niclosamide and Trehalose alone and in combination with each other against standard Leishmania major in vitro and in vivo. 2023 to present | Isfahan University of Medical Sciences (Isfahan, IR). Part of GRANT_NUMBER: IR.MUI.AEC.1401.047 - Investigating the Inhibitory effect of hsa-piR-33195 on cell proliferation and apoptosis in human non-promyelocytic acute myeloid leukemia cells. 2023 to present | Isfahan University of Medical Sciences (Isfahan, IR) Part of GRANT_NUMBER: IR.MUI.MED.REC.1402.215 - Immunotherapies targeting tumor vasculatures: challenges and opportunities. 2023 to 2023 | Grant Isfahan University of Medical Sciences (Isfahan, IR) GRANT_NUMBER: 2402102 -Evaluation of Trehalose and Niclosamide, alone and in combination against Leishmania major in vitro. 2022 to present | Isfahan University of Medical Sciences (Isfahan, IR)= Part of GRANT_NUMBER: R.MUI.MED.REC.1401.433

Patents :

-

Presentations & Poster Sessions :

 H. Dianat-Moghadam, M. Khalili, F. S. Mahdaviani, Future directions for applying Hematopoietic Stem Cell in transfusion Medicine, 11th International Congress of Laboratory and Clinic, Tehran, Iran (16/01/2019)  M. Khalili, H. Dianat-Moghadam, F. S. Mahdaviani, M. R. Soleyman, Application of CRISPR/Cas9 gene editing technology to increase RBC compatibility for blood transfusion, 11th International Congress of Laboratory and Clinic, Tehran, Iran (17/01/2019)  Mostafa Khalili, Shima Abbasi, Hassan Dianat-Moghadam, Fateme Sadat Mahdaviani. The Effects of Platelet-rich Plasma on Cell Proliferation, Adhesion and Spreading of Human Adiposederived Stem Cells and Preserves Their Stemness. 13th International Congress of Laboratory and Clinic, Tehran, Iran (February 2022).

Research Experience :

- Cloning and expression of e recombinant human keratinocyte growth factor in eukaryotic HEK293T cells - Control of cancer stem cells' metabolism and growth using immunoliposomal NPs loaded with LXR antagonist/agonist - Antibacterial activity of green gold and silver NPs using ginger root extract - Isolation of cfDNA from spent culture media and its association with implantation rate and maternal immunomodulation - PCL/Col I-based magnetic nanocomposite scaffold provides an osteoinductive environment for ADSCs in osteogenic cues-free media conditions - Corneal endothelial cell sheet bioengineering from neural crest cell-derived adipose stem cells on novel thermo-responsive elastin-mimetic dendrimers decorated with RGD -Oncolytic Newcastle disease virus delivered by Mesenchymal stem cells-engineered system enhances the therapeutic effects altering tumor microenvironment - Oncolytic Newcastle disease virus reduces growth of cervical cancer cell by inducing apoptosis - Micronuclei assessment of the radioprotective effects of melatonin and vitamin C in human lymphocytes - Typing and Evaluation of the Genetic Relatedness of Listeria monocytogenes Strains Isolated from Food Samples by the Multiple-Locus Variable number Tandem Repeat Analysis (MLVA)

Research Interests :

- Isolation, identification and targeting Cancer Stem Cells (CSCs) - Implication of Stem Cells (SCs) in Regenerative Medicine - Applications of Bionanotechnology in Vaccine Developmen - Targeted therapy


Teaching Experience :

• Teaching Molecular and Advanced Techniques to the BSc Students of Clinical laboratory sciences, Isfahan University of Medical Sciences, Isfahan, Iran, 2022
• Teaching Immuno-biochemistry and Analysis Methods to M.Sc. Students of Medical Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran, 2022-…
• Teaching Genetics of Cancer to M.Sc. Students of Medical Genetic, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…
• Teaching seminar I to M.Sc. students of Medical Genetic/Biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…
• Teaching cellular and molecular biology to the BSc students of clinical laboratory sciences, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…
• Teaching cellular biology to the BSc students of radiology, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…
• Teaching cellular and molecular biology to the M.Sc. students of medical microbiology, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…
• Teaching cellular and molecular biology to the M.Sc. students of medical biotechnology, Isfahan University of Medical Sciences, Isfahan, Iran, 2023-…

Teaching Interests :

- Cellular and molecular biology
- Molecular immunology
- vaccines
- Genetic engineering
- Tumor biology/therapy
- stem cells and applications
- Nanobiotechnology